Oxidized LDL, insulin sensitivity and beta-cell function in newborns

Glyc-oxidized LDL impair endothelial function more potently than oxidized LDL: role of enhanced oxidative stress.

Hypercholesterolemia is associated with impairment of endothelial function due to increased levels of LDL. In diabetic patients, however, attenuation of endothelial function occurs even under normocholesterolemic conditions. Here we assessed whether glycation of LDL potentiates their influence on endothelial function, with particular emphasis on the oxidizability of LDL and the role of O2-. Hum...

The effect of regular aerobic training on beta cell function and serum insulin in sedentary male\'s smoker

Previous studies have shown that nicotine can affect beta cell function and insulin secretion in cigarette smokers. The aim of present study was to evaluate the effect of 10 weeks aerobic exercise on insulin and beta cell function in smokers. In this semi-experimental study with pre and post-training design, a total of 36 adult smoker men aged 41±2.5 years were selected into either exerc...

Adiponectin in youth: relationship to visceral adiposity, insulin sensitivity, and beta-cell function.

OBJECTIVE Adiponectin is an adipose tissue protein that enhances insulin sensitivity and has antiatherogenic properties. The present study investigated the relationship of adiponectin levels in adolescents to 1) obesity and body fat distribution and 2) insulin sensitivity and the components of syndrome X. RESEARCH DESIGN AND METHODS Twenty-three normal-weight and 26 obese adolescents had fast...

Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and beta-cell function.

Iron-related insulin-resistance is improved by iron depletion or treatment with iron chelators. The aim of this study was to evaluate insulin sensitivity and insulin secretion after blood letting in patients who had high-ferritin type 2 diabetes and were randomized to blood letting (three phlebotomies [500 ml of blood] at 2-week intervals, group 1) or to observation (group 2). Insulin secretion...

Insulin sensitivity and beta-cell function in older Japanese adults without diabetes.